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Cytotec: composition, indications, dosage, side effects

It is a uterotonic, labor-promoting, anti-ulcer, gastroprotective agent. It induces contraction of smooth muscle fibers of myometrium, dilation of the cervix. Facilitates opening of the cervix, increases uterine tone, can provoke miscarriage. It has antisecretory activity. It is able to bind to PGE receptors of the parietal cells of the stomach, inhibiting basal, stimulated, and nocturnal secretion of gastric juice. It enhances the formation of bicarbonate, mucus, shows cytoprotective effect, improves blood flow. Increases the resistance of the mucous membrane of the stomach, prevents the development of erosive and ulcerative lesions, stimulates the healing of peptic ulcers. It has a weak stimulating effect on the smooth muscle fibers of the gastrointestinal tract.

Misoprostol has no clinically significant effect on gonadotropin levels, prolactin, thyroid hormone, thyroxine, growth hormone, creatinine, cortisol, platelet aggregation, lung function, cardiovascular system.

Administration of Cytotec:

  • In gastric ulcers, duodenal ulcers;
  • In ulcers induced by nonsteroidal anti-inflammatory drugs;
  • For the prevention of peptic ulcer disease in the treatment with ulcerogenic drugs.
  • For stimulation of myometrium contraction, cervical dilation;
  • For early termination of pregnancy (up to 49 days) in combination with mifepristone.

Cytotec should not be prescribed:

  • If you are intolerant to misoprostol, auxiliary components of the drug;
  • In severe hepatic insufficiency;
  • In inflammatory diseases of the digestive tract;
  • In cardiovascular diseases;
  • In diseases of the liver, kidneys;
  • In diseases associated with prostaglandin addiction;
  • In the presence of contraindications to the use of prostaglandins (bronchial asthma, glaucoma, arterial hypertension, endocrinopathy, diabetes, adrenal dysfunction);
  • In hormone-dependent tumors;
  • Anemia;
  • In the use of intrauterine contraceptives (prior to use it is necessary to remove the STR);
  • In case of suspected ectopic pregnancy.

Misoprostol causes uterine contractions and may result in termination of pregnancy, complete or partial abortion, congenital abnormalities, and fetal death. First trimester use is associated with a significant increase in the risk of birth defects. Breast-feeding is stopped for 7 days after taking the drug.

“The active ingredient: misoprostol (200 mcg). Available in tablet form. Manufacturer: Pfizer Inc.”

Dosage and administration

Cytotec is administered orally (orally) with meals. The standard dose for adults with gastrointestinal ulcers is 200 micrograms 4 times a day for 4-8 weeks. With the preventive purpose is prescribed 100-200 mcg 2-4 times a day.

Healthy pregnant women with amenorrhea of less than or equal to 49 days are prescribed 400 micrograms (36 to 48 hours after mifepristone 600 mg) for the purpose of termination of pregnancy.

Symptoms indicating possible overdose: symptoms of gastrointestinal dysfunction, weakness, shortness of breath, tremors, seizures, abdominal pain, palpitations, diarrhea, fever, bradycardia, arterial hypotension. Treatment: symptomatic therapy is indicated.

Immune disorders: anaphylactic reactions.

Neurological disorders: headache, fainting spells, dizziness.

Gastrointestinal disorders: nausea, abdominal pain, dyspepsia, constipation, flatulence, vomiting.

Dermatological disorders: rash, redness, itching, urticaria.

Obstetric and gynecological disorders: amniotic fluid embolism, fetal death, abnormal uterine contractions, fetal distress syndrome, premature labor, incomplete abortion, hyperstimulation, uterine rupture, reproductive tract infection, uterine perforation, vaginal bleeding, intermensural bleeding, uterine cramps, dysmenorrhea (menstrual cycle disorders), prolonged menstrual bleeding, uterine bleeding.

Congenital and genetic disorders: congenital fetal defects.

Others: trembling, fever, chills, feeling of fatigue.

The drug Cytotec must be stored in undamaged packaging at a temperature of up to +30 degrees Celsius for no more than three years.